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Dosing

With Cannabis

HOW DO WE MEASURE BALANCE IN THE ENDOCANNABINOID SYSTEM AND WHEN IS IT NOT IN A STATE OF BALANCE? 

As a lab tech from Cannalabs in Colorado wrote, "Just about anyone with clinical signs/symptoms of obese-central metabolic syndrome, pain, anxiety, depression, sleep disturbance and or inflammatory/immune dysfunction will likely have some sort of ECS imbalance that can be part of a multifaceted therapeutic strategy to manage these conditions….in healthy or not so healthy individuals".

3 TECHNIQUES TO ACCURATELY MEASURE BALANCE IN THE ENDOCANNABINOID SYSTEM.

  • Brain Scans

    • Very few doctors have access this tech and insurance companies are unlikely to pay for it.

  • Liquid Chromatography

    • Many labs are doing amazing things with this technology.

  • Microdialysis  as a sampling technique

    • The idea is to measure the extracellular fluid levels around CB1 and CB2 receptors. Fairly simple and minimally invasive, it is a simple blood draw and again uses microdialysis as a sampling technique. Shamefully this cutting-edge technology in the 80’s is still only being used currently on research with animals.

DOSING

The cannabis plant produces a very balanced ecology of chemical compounds that play well with a host of the system in our body that are controlled by the endocannabinoid system.

Cannabis, and its constituents, in medicinal marijuana or possibly CBD Oil, acts as a homeostatic regulator keeping the ECS in balance thus balancing your biology.

This balance is directly related to dosing, however, “MORE IS NOT BETTER”.

Multiple studies have shown that low doses cannabis sativa are particularly effective for most levels of neuropathic pain. The point being higher levels can throw your ECS out of balance and should be avoided.

 

Cannabis Dose Studies

Researchers in Israel:

LOW DOSE VAPORIZED CANNABIS SIGNIFICANTLY IMPROVES NEURO PATHIC PAIN

  • Conclusion of the results were then low doses of cannabis work effectively well against most levels of neuropathic pain such as those experienced by suffers of arthritis, muscular dystrophy, fibromyalgia, and many other painful conditions.

Researchers in Spain

DOSE-DEPENDANT EFFECTS OF SMOKED CANNABIS ON CAPSAICIN-INFUCED PAIN AND HYPERALGESIA IN HEALTHY VOLUNTEERS.

The scientists had volunteers apply capsaicin (essentially Bengay cream) to their forearm and blow on it.  The result of doing this is a particularly good model for pain.  Then they administered low, medium and high doses of cannabis.  What they found was that at low levels there was essentially no pain relief, at moderate levels there was excellent pain relief and most significantly, at high levels there was no pain relief or even increased pain,

Researchers in the United States

Reversible and regionally selective down regulation of brain cannabinoid CB1 receptors in chronic daily cannabis smokers.

  • The results of this study are fascinating because the scientists collected people that had been smoking 30 joints a day for years and so obviously had time to devote to an in-patient study!

  • These are also people whose endocannabinoid system was pretty well down regulated (out of balance) because they were ingesting so much THC.

  • What the researchers wanted to prove was that marijuana cause brain damage (the only way to get permission to study cannabis in this country is by attempting to prove it causes harm.) So, they basically locked these people up for 28 days and did not allow them any cannabis. After 28 days their endocannabinoid system returned to normal baseline levels in all participants as documented by brain scans.  This study demonstrates that you can smoke 30 joints a day for years, stop for 28 days and your endocannabinoid system essentially gets a reset. ( you can also get a reset by adding a little CBD to the cannabis mix.)